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单位:西南医科大学基础医学院
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张禄滑

发布时间:2024-11-01 17:34:20 点击率: 字体大小:

张禄滑,男,伊利诺伊大学香槟分校联合培养博士。现就职于西南医科大学基础医学院病原生物学教研室,副教授,硕士研究生导师,中国微生物学会会员,美国微生物学会会员。承担国家自然科学基金项目1项,省部级项目1项,厅局级等项目多项,入选西南医科大学青年人才培育项目,以第一或通讯作者发表SCI论文30余篇,参编教材两部,担任BMC microbiology等多个期刊审稿人,获评西南医科大学优秀个人。

近5年指导研究生多人次荣获四川省优秀大学毕业生、国家奖学金、一等奖学金、泸州老窖奖学金等。

1.招生方向:病原生物学

2.研究方向:病原菌的耐药机制;耐药菌的噬菌体治疗

3.联系方式:zhluhua@swmu.edu.cn

4.导师寄语:在科研路上,坚持比天赋更长久,认真比聪明更可靠。愿你沉下心、稳住神,一步一个脚印,走出属于自己的学术之路。

5.主要承担项目

(1)RfaH通过调控荚膜多糖合成介导肺炎克雷伯菌持留进化的作用研究,国家自然科学基金青年基金,主持;

(2)质粒介导的替加环素耐药基因传播机制研究,四川省科技厅项目,主持。

6.代表性论文

(1) Yin M, Cao L, Fu Y, Lu Y, Yan Y, Qian L, Xiang L, Zhou T, Chen H, Li Y, Zhang L. 2025. A novel tail fiber protein triggers phage DNA ejection by recognizing lipopolysaccharides of K54 hypervirulent Klebsiella pneumoniae. Microbiology Spectrum:e02171-02125. (中科院2区)

(2) Fu Y, Yin M, Cao L, Lu Y, Li Y, Zhang L. 2025. Capsule mutations serve as a key strategy of phage resistance evolution of K54 hypervirulent Klebsiella pneumoniae. Communications Biology 8:257. (中科院1区)

(3) Qiu Y, Xiang L, Yin M, Fang C, Dai X, Zhang L, Li Y. 2024. RfaH contributes to maximal colonization and full virulence of hypervirulent Klebsiella pneumoniae. Frontiers in Cellular and Infection Microbiology 14. (中科院2区)

(4) Fang C, Dai X, Xiang L, Qiu Y, Yin M, Fu Y, Li Y, Zhang L. 2023. Isolation and characterization of three novel lytic phages against K54 serotype carbapenem-resistant hypervirulent Klebsiella pneumoniae. Frontiers in cellular and infection microbiology 13:1265011. (中科院2区)

(5) Li Y, Fu Y, Qiu Y, Liu Q, Yin M, Zhang L. 2023. Genomic characterization of tigecycline-resistant Escherichia coli and Klebsiella pneumoniae isolates from hospital sewage. Frontiers in Microbiology 14:1282988.(中科院2区)

(6) Li Y, Liu Q, She J, Qiu Y, Dai X, Zhang L. 2023. IS26-mediated in vivo acquisition of blaKPC-2 in an ST11-K64 Klebsiella pneumoniae isolate from a senile inpatient. Journal of Antimicrobial Chemotherapy 78:550-553. (中科院2区)

(7) Li Y, Qiu Y, Fang C, Dai X, Zhang L. 2022. Coexistence of blaOXA-58 and blaNDM-1 on a Novel Plasmid of GR59 from an Acinetobacter towneri Isolate. Antimicrobial Agents and Chemotherapy 66: e0020622. (中科院2区)

(8) Li Y, Qiu Y, Fang C, Dai X, Zhang L. 2022. Genomic characterization of a multidrug-resistant Aeromonas caviae isolate carrying a novel blaKPC-2-harbouring plasmid and an IMP-4-encoding phage-like plasmid. Microbiology Spectrum 10:e00840-00822. (中科院2区)

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