袁青，博士、女、西南医科大学基础医学院免疫学教研室主任，科技处公共实验技术中心免疫学技术平台主任，三级教授，西南医科大学硕士生导师，留美访问学者、澳门科技大学兼职博士生导师、泰国清迈大学兼职博士生导师、四川省生物信息学会智慧免疫学分会副会长、四川省科技青年联合会常务理事、中国免疫学会理事。入选四川省杰出青年学术技术带头人资助计划、为四川省学术技术带头人后备人选、四川省卫生健康英才、泸州市拔尖人才、泸州市学术技术带头人。近年主要从事炎症与肿瘤的免疫学发病机制及抗体治疗研究，主持包括国家自然科学基金、四川生杰出青年学术技术带头人资助计划等各类科研课题近20项。以第一和通讯作者发表SCI论文30余篇，以第一申请人申请和获批国家发明专利6项，其中一项成功转让。
1. 学习及工作经历
1997/09-2001/07，西南大学，学士
2001/09-2004/07，西南大学，分子微生物学方向，硕士
2004/09-2007/07，重庆大学，生物工程学院生物制药方向，博士
2009.10-至今，西南医科大学，基础医学院免疫学教研室
其中2009/08-2012/01，USDA, Maryland，交流访问学者
2. 联系方式
邮箱：123845459@qq.com
3. 研究方向：
炎症与肿瘤的免疫机制及免疫治疗
4. 承担的代表项目：
1) 国家自然科学基金，31000415、抗IL-4、IL-33新型双特异性抗体的构建及其对哮喘气道炎症的影响、2011.01-2013.012、项目主持;
2) 四川省杰出青年学术技术带头人资助计划、2012JQ0018、改进型大库容量人源抗体文库构建及新品种人源抗体制备、2012.01-2014.12、项目主持。
3) 四川省科技厅项目、2015JY0218、抗IL-33全人源scFv-Fc抗体对哮喘的治疗作用及机制、2015.01-2017.12、项目主持。
4) 四川省科技厅-西南医科大联合项目、14ZC0021、治疗B细胞淋巴瘤全人源重组抗体研发、2014.07-2017.07、项目主持。
5) 四川省教育厅创新团队项目、16TD0022、治疗恶性肿瘤全人源重组抗体药物研发、2016.01-2018.12、项目主持。
6) 泸州市-西南医科大学联合项目(青年创新团队培育)、2017LZXNY D-T06、新型抗体-抗生素偶联物对MRSA感染的治疗作用、2017.07-2020.07、项目主持.
7) 四川大学-泸州市人民政府战略合作项目、2020CDLZ-24、抗体药物与靶向治疗重点实验室、2021.01-2023.12、项目主持。
8）四川省科技计划项目、创新专项-面上、基于联合免疫治疗策略个性化精准治疗非小细胞肺癌的免疫评价体系的建立、2022.01-2024.12、项目主持。
5. 代表性论文：
1） Lin Li, Siji Nian, Qin Liu, Bo Zhang, Wulemo Jimu, Chengwen Li Zhanwen Huang, Qiaosen Hu, Yuanshuai Huang, Qing Yuan*. Fully human anti-B7-H3 recombinant antibodies inhibited tumor growth by increasing T cell infiltration. International Immunopharmacology, 2024，132:111926.
2）Xuyuan Huang, Hao Chi, Siqi Gou, Xiyuan Guo, Lin Li, Gaoge Peng, Jinhao Zhang, Jiayu Xu, Siji Nian, Qing Yuan*. An Aggrephagy-Related LncRNA Signature for the Prognosis of Pancreatic Adenocarcinoma. Genes, 2023,14:124.
3) Pengyuan Kang, Dan Liu, Lin Li, Xiyuan Guo, Yingchun Ye, Yunfei Li, Qin Jiang, Sheng Lin, Qing Yuan*. Interleukin 8 in plasma is an efficacy marker for advanced non-small cell lung cancer treated with hypofractionated radiotherapy and PD-1 blockade. Cytokine, 2023, 163: 156133.
4）Pengyuan Kang, Hong Yu, Yunfei Li, Xue Wen, Hua Ye, Yuhao Luo, Yaqi Yang, Qing Yuan*, and Sheng Lin*. Tracking PeripheralMemory T Cell Subsets inAdvanced Nonsmall Cell Lung Cancer Treated with Hypofractionated Radiotherapy and PD-1 Blockade. Journal of Oncology, 2023, 3221510.
5) Zixi Xu, Yingchun Ye, Guoping Huang, Yi Li, Xiyuan Guo, Lin Li, Yuchuan Wu, Wenfeng Xu, Siji Nian, Qing Yuan*. EphA2 recognizes Dermatophagoides pteronyssinus to mediate airway inflammation in asthma. International Immunopharmacology, 2022, 111: 109106.
6) Xue Wen, Siji Nian, Guang Wei, Pengyuan Kang, Yaqi Yang, Lin Li, Yingchun Ye, Lulu Zhang, Songping Wang, Qing Yuan*. Changes in the phenotype and function of mucosal-associated invariant T cells in neutrophilic asthma. International Immunopharmacology, 2022, 106: 108606.
7) Xingli Zhang, Zixi Xu, Xue Wen, Guoping Huang, Siji Nian, Lin li, Xiyuan Guo, Yingchun Ye, Qing Yuan*. The onset, development and pathogenesis of severe neutrophilic asthma. Immunology & Cell Biology, 2022, 100(3):144-159.
8）Pengyuan Kang, Yunfei Li，Zhi Hu, Ming Lei, Jun Cheng, Xiyuan Guo, Lulu Zhang, Sheng Li，Qing Yuan*. Neuropilin-1 is a valuable biomarker for predicting response of advanced non-small cell lung cancer patients to hypofractionated radiotherapy and PD-1 blockade. International Immunopharmacology, 2022,109:108732.
9) Wenfeng Xu, Lei Peng, Chun Li, Tong Wu, Han Chen, Haiyan Zhang, Hong Yu, Yingchun Ye, Yuchuan Wu, Qing Yuan*, Siji Nian*. A novel fully human recombinant antibody neutralizing a-hemolysin of Staphylococcus aureus. APMIS. 2022, 130(9):578-589.
10）Qi Chen, Siji Nian, Yingchun Ye, Dan Liu, Hong Yu, Hong Xiong, Bi Pan, Lu Xiao, Chunrong Fan, Qing Yuan*. The Emerging Roles of T Helper Cell Subsets and Cytokines in Severe Neutrophilic Asthma, inflammation, 2022, 45(3), 1007-1022.
11) Yaqi Yang, Siji Nian, Lin Li, Xue Wen, Qin Liu, Bo Zhang, Yu Lan, Qing Yuan*, Yingchun Ye*. Fully human recombinant antibodies against EphA2 from a multi-tumor patient immune library suitable for tumor-targeted therapy. Bioengineered, 2021,12(2):10379-10400.
12) Haiyan Zhang, Yongfei Xie, Zhi Hu, Hong Yu, Xiang Xie, Yingchun Ye, Wenfeng Xu,Siji Nian and Qing Yuan*. Integrative analysis of the expression of siglec family members in lung adenocarcinoma via Data Mining. Frontiers in Oncology, 2021, 3(11): 608113.
13) Xue Wen, Xingli Zhang, Siji Nian, Gang Wei, Xiyuan Guo, Hong Yu, Xiang Xie, Yingchun Ye, Qing Yuan*. Mucosal-associated invariant T cells in lung disease. International immunopharmacology, 2021(94): 107485.
14）Qi Chen, Shengmin Guo, Houqiang Huang, Guoping Huang, Yi Li, Zihui Li, Run Huang, Lu Xiao, Chunrong Fan, Qing Yuan*, Silin Zheng*. Long noncoding RNA SBF2-AS1 contributes to the growth and metastatic phenotypes of NSCLC via regulating miR-338-3p/ADAM17 axis. AGING 2020, 12(18):17902-17920.
15) Qi Chen, Dequn Xian, Wenfeng Xu, Siji Nian, Hong Yu, Yuchuan Wu, Qing Yuan*. Affinity improvement of the fully human anti-TSLP recombinant antibody. Molecular medicine reports, 2020, 21: 759-767.
