一、团队负责人
袁青 博士,教授,硕士生导师,博士生导师。
二、团队主要人员
袁青 教授
李成文 教授
邬于川 教授
刘佳佳 教授
任德莲 教授
高燕 副教授
于红 博士
谢翔 博士
郑小莉 博士
曹新梅 在读博士
王栩 硕士
黄黎 硕士
周云刚 硕士
郭夕源 硕士
吴小萍 硕士
徐文峰 实验员
三、研究方向
经过近10年的建设,本学科研究团队现已形成四个较稳定的研究方向:(1)炎症调控方向(2)肿瘤免疫研究方向(3)全人源抗体研究(4)移植免疫研究方向。
四、主要论文(*,通讯作者;+并列第一)
1. Qing Yuan (袁 青), Ramon Jordan, Ronald H. Brlansky, Olga Minenkowa, John Hartung*. Development of single chain variable fragment (scFv) antibodies against surface proteins of “Ca. Liberibacter asiaticus’. Journal of Microbiological Methods, 2016 (122)1-7.
2. Siji Nian, Tong Wu, Yingchun Ye, Xu Wang, Wenfeng Xu, Qing Yuan* (袁 青). Development and identificaction of fully human scFv-Fcs against staphylococcus. Aureus. BMC Immunology. 2016, 17:8.
3. Yingchun Ye, Siji Nian, Wenfeng Xu, Tong Wu, Yan Gao, Qing Yuan* (袁青). Construction and expression of human scFv-Fc against interleukin-33. Protein Expr Purif. 2015, 114: 58-63.
4. Qing Yuan (袁 青), Ramon Jordan, Ronald H. Bransky, Olga Istomina, John Hartung*. Development of single chain variable fragment (scFv) antibodies against Xylella fastidiosa subsp. pauca by phage display. Journal of Microbiological Methods, 2015(17): 148-154.
5. Yu H(于红), Soler M, et al. Comprehensive genome-wide analysis of Aux/IAA gene family in Eucalyptus: evidence for the role of EgrIAA4 in wood formation. Plant Cell Physiol. 2015, 56: 700-14.
6. Li Q, Yu H+(于红), et al. Explosive tandem and segmental duplications of multigenic families in Eucalyptus grandis. Genome Biol Evol. 2015, 7: 1068-81.
7.Yu H(于红), Soler M, et al. Genome-Wide characterization and expression profiling of the AUXIN RESPONSE FACTOR (ARF) gene family in Eucalyptus grandis.2014, PloS one 9: e108906.
8. Xiang Xie(谢翔),Ju Tan, Dangheng Wei, Daoxi Lei, Tieying Yin, Junli Huang, Xiaojuan Zhang, Guixue Wang*. In vitro and in vivo investigation on the effects of LDL concentration polarization and hemodynamics on atherosclerotic localization in rabbit and zebrafish. J R Soc Interface. 2013, 28:10(82):20121053.
9.Qing Yuan(袁 青), Siji Nian, Xiyuan Guo, Yan Gao and Jiajia Liu*. Construction of a naïve human phage scFv library and selection, identification of human scFvs. Front. Immunol, 2013, doi: 10.3389/conf. fimmu.2013.02.00521. (Abstract).
10. Siji Nian, Qing Yuan*(袁 青), Li Huang, Yingchun Ye and Yuchuan Wu. Development and affinity matureation scFv against IL-4 and IL-13 by pgage display. Front. Immunol, 2013, doi: 10.3389/conf. fimmu.2013.02.00762. (Abstract).
11. Qing Yuan (袁 青), Li Huang, Xu Wang, Yuchuan Wu, Yan Gao,Chengwen Li, Siji Nian*. Construction of human nonimmune library and selection of scFvs against IL-33. Applied Biochemistry and Biotechnology, 2012, 167: 498-509.
12. Luo L, Li C W+ (李成文), Wu W, Lu J, Shan J, Li S, Long D, Guo Y, Feng L, Li Y. Dendritic cells transduced with lentiviral vector targeting RelB gene using RNA interference induce hyporesponsiveness in memory CD4+T cells and naïve CD4+T cells. Cell Immunol. 2012, 273:85-93.
五、专利
1.专利名称:松材线虫分子检测快速制样方法;授权时间及国别:2010年专利类别:发明;专利号:ZL200710092787.9,第3发明人。
2.专利名称:小麦矮腥黑穗病菌实时荧光PCR固相化试剂盒及其检测方法;授权时间及国别:2010年,专利类别:发明;专利号:ZL200610054091.2;第4发明人。
3.专利名称:马铃薯病毒病两步法多重RT-PCR固相化检测试剂盒及检测方法;授权时间及国别:2008年,中国;专利类别:发明;专利号:ZL200610054159.7,第3发明人。
4.专利名称:柑桔溃疡病菌实时荧光PCR检测引物、探针、固相化试剂盒及其检测方法;授权时间及国别:2008年,专利类别:发明;专利号:ZL200510057477.4;第4发明人。
5.专利名称:柑桔黄龙病菌实时荧光PCR检测引物、探针、固相化试剂盒及其检测方法;授权时间及国别:2008年,专利类别:发明;专利号:ZL200510057478.9;第4发明人。
六、成果
1. 袁青,年四季,郑小莉,于红,李成文,叶迎春等,全人源抗体技术体系及新型治疗性全人源抗体构建研究,2015年泸州市科技进步奖二等奖。