一、团队负责人
代荣阳 博士，教授，硕士生导师，澳门科技大学兼职博士生导师，哈佛医学院访问学者，教育部新世纪优秀人才支持计划获得者，四川省学术技术带头人后备人选。
二、团队主要人员
代荣阳博士；
赵晓芳博士；
周虹博士；
成鹰博士；
姚富丽博士；
李玉筱博士；
甘淋博士；
刘秋均博士；
等。
三、研究方向
研究团队致力于肝胆疾病细胞信号调控研究，目前主要从事应激反应与肝胆疾病的关系研究。
四、主要论文（*，通讯作者；+并列第一）
[01]Feng C, He K, Zhang C, Su S, Li B, Li Y, Duan CY, Chen S, Chen R, Liu Y, Li H, Wei M, Xia X, Dai R*. JNK Contributes to the Tumorigenic Potential of Human Cholangiocarcinoma Cells through the mTOR Pathway Regulated GRP78 Induction. PLoS One. 2014;9(2):e90388.
[02]RY Dai, XF Zhao, JJ Li, R Chen, ZL Luo, LX Yu, SK Chen, CY Zhang, CY Duan, YP Liu, CH Feng, XM Xia, H Li, J Fu, HY Wang*. Implication of transcriptional repression in compound C-induced apoptosis in cancer cells. Cell Death Dis. 2013;4:e883.
[03]Chen R, Duan CY, Chen SK, Zhang CY, He T, Li H, Liu YP, Dai RY*. The suppressive role of p38 MAPK in cellular vacuole formation. J Cell Biochem. 2013;114:1789-99.
[04]Chen R, Li J, Feng C, Chen S, Liu Y, Duan C, Li H, Xia X, He T, Wei M, Dai R*. c-Met function requires N-linked glycosylation modification of pro-Met. J Cell Biochem. 2013;114(4):816-22.
[05]Dai R, Li J, Fu J, Chen Y, Wang R, Zhao X, Luo T, Zhu J, Ren Y, Cao J, Qian Y, Li N, Wang H*. The Tyrosine Kinase c-Met Contributes to the Pro-tumorigenic Function of the p38 Kinase in Human Bile Duct Cholangiocarcinoma Cells. J Biol Chem. 2012;287(47):39812-23.
[06]Dai R, Li J, Fu J, Chen Y, Yu L, Zhao X, Qian Y, Zhang H, Chen H, Ren Y, Su B, Luo T, Zhu J, Wang H*. Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells. J Biol Chem. 2012;287(18):14586-97.
[07]Dai R, Yan D, Li J, Chen S, Liu Y, Chen R, Duan C, Wei M, Li H*, He T. Activation of PKR/eIF2α signaling cascade is associated with dihydrotestosterone-induced cell cycle arrest and apoptosis in human liver cells. J Cell Biochem. 2012;113(5):1800-8.
[08]Run Chen, Rongyang Dai +, Chunyan Duan, Youping Liu, Shaokun Chen, Dongmei Yan, Chuanning Chen, Mei Wei, Hong Li*. Unfolded Protein Response Suppresses Cisplatin-induced Apoptosis via Autophagy Regulation in Human Hepatocellular Carcinoma Cells. Folia Biol (Praha). 2011;57(3):87-95.
[09]Liu Y, Liu P, Dai R+, Wang J, Zheng Y, Shen J, Guo F, Wang L, Li H, Wei M*. Analysis of plasma proteome from cases of the different traditional Chinese medicine syndromes in patients with chronic hepatitis B. J Pharm Biomed Anal. 2012;59:173-8.
[10]Rongyang Dai, Juan Li, Youping Liu, Dongmei Yan, Shaokun Chen, Chunyan Duan, Xiaoyan Liu, Tao He, Hong Li*. MiR-221/222 suppression protects against endoplasmic reticulum stress-induced apoptosis via p27Kip1- and MEK/ERK-mediated cell cycle regulation. Biol Chem. 2010;391(7):791-801.
[11]Rongyang Dai, Shaokun Chen, Dongmei Yan, Run Chen, Youping Liu, Chunyan Duan, Juan Li, Tao He, Hong Li*. PI3K/Akt promotes GRP78 accumulation and inhibits endoplasmic reticulum stress-induced apoptosis in HEK293 cells. Folia Biol(PRAHA). 2010;56(2):37-46.
[12]Rong-Yang Dai, Yao Chen, Jing Fu, Li-Wei Dong, Yi-Bin Ren, Guang-Zhen Yang, You-Wen Qian, Jie Cao, Shan-Hua Tang, Sheng-Li Yang and Hong-Yang Wang*. p28GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity. Cell Res. 2009;19(11):1243-57.
[13]Dai R, Chen R, Li H*. Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stress-induced cell cycle progression and cell death in human hepatocellular carcinoma cells. Int J Oncol. 2009;34(6):1749-57.
[14]Zhang HL, Yu LX, Yang W, Tang L, Lin Y, Wu H, Zhai B, Tan YX, Shan L, Liu Q, Chen HY, Dai RY, Qiu BJ, He YQ, Wang C, Zheng LY, Li YQ, Wu FQ, Li Z, Yan HX, Wang HY*. Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. J Hepatol. 2012;57(4):803-12.
[15]Cao J, Chen Y, Fu J, Qian YW, Ren YB, Su B, Luo T, Dai RY, Huang L, Yan JJ, Wu MC, Yan YQ, Wang HY*. High Expression of Proline-Rich Tyrosine Kinase2 is Associated with Poor Survival of Hepatocellular Carcinoma via Regulating Phosphatidylinositol 3-Kinase/AKT Pathway. Ann Surg Oncol. 2013; 20(Suppl 3):S312-23.
[16]Qian YW, Chen Y, Yang W, Fu J, Cao J, Ren YB, Zhu JJ, Su B, Luo T, Zhao XF, Dai RY, Li JJ, Sun W, Wu MC, Feng GS, Wang HY*. p28GANK prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. Gastroenterology. 2012;142(7):1547-58.
[17]Li-wei Dong, Guang-zhen Yang, Yu-fei Pan, Yao Chen, Ye-xiong Tan, Rong-yang Dai, Yi-bin Ren, Jing Fu, Hong-yang Wang*. The oncoprotein p28GANK establishes a positive feedback loop in β-catenin signaling. Cell Res. 2011;21(8):1248-61.
[18]冯春红,陈润,陈绍坤,李娟,段春燕,刘友平,李洪,代荣阳*. 真核起始因子2α的磷酸化抑制顺铂介导的肝癌细胞凋亡.中华肝脏病杂志, 2013;21(04):290-4. (Medline收录)
[19]Zhao X, Fu J, Xu A, Yu L, Zhu J, Dai R, Su B, Luo T, Li N, Qin W, Wang B, Jiang J, Li S, Chen Y, Wang H. Gankyrin drives malignant transformation of chronic liver damage-mediated fibrosis via the Rac1/JNK pathway. Cell Death Dis. 2015;6:e1751.
[20] Luo T, Fu J, Xu A, Su B, Ren Y, Li N, Zhu J, Zhao X, Dai R, Cao J, Wang B, Qin W, Jiang J, Li J, Wu M, Feng G, Chen Y, Wang H. PSMD10/Gankyrin Induces Autophagy to Promote Tumor Progression through Cytoplasmic Interaction with ATG7 and Nuclear Transactivation of ATG7 Expression. Autophagy. 2016 ;12(8):1355-71.
[21] Du J, Tao ZH, Li J, Liu YK, Gan L. Construction of a hepatocellular carcinoma cell line that stably expresses stathmin with a Ser25 phosphorylation site mutation. Genet Mol Res. 2015,14(4):12111-12117.（IF:0.764）
[22] Guo K, Gan L, Zhang S, Cui FJ, Cun W, Li Y, Kang NX, Gao MD, Liu KY.Translocation of HSP27 into liver cancer cell nucleus may be associated with phosphorylation and O-GlcNAc glycosylation. Oncol Rep. 2012 ,28(2):494-500.（IF:2.486）
[23]Gong S, Tao Z, Liu X, Gan L . An underlying prognosis predictor of hepatocellular carcinoma: Oncoprotein 18. Biomed Rep. 2014,2(1):85-88.]
[24] Fuli Yao, Yazhen Liu, Linyong Du, Xinyan Wang, Anying Zhang, He Wei, Hong Zhou*. Molecular identification of transcription factor Runx1 variants in grass carp (Ctenopharyngodon idella) and their responses to immune stimuli. Vet Immunol Immunopathol. 2014,160 (3-4):201-208. (IF: 1.748 )
[25] Fuli Yao, Xiao Yang, Xinyan Wang, He Wei, Anying Zhang, Hong Zhou*. Molecular and functional characterization of an IL-1β receptor antagonist in grass carp (Ctenopharyngodon idella). Dev Comp Immunol. 2015,49(2):207-216. (IF: 3.62 )
[26] Cheng Y, Kuang W, Hao Y, Zhang D, Lei M, Du L, Jiao H, Zhang X, Wang F.
Downregulation of miR-27a* and miR-532-5p and upregulation of miR-146a and miR-155 in LPS-induced RAW264.7 macrophage cells[J].Inflammation. 2012, 35(4):1308-13.
[27] Cheng Y, Du L, Shi Q, Jiao H, Zhang X, Hao Y, Rong H, Zhang J, Jia X, Guo S, Kuang W, Zhang H, Chen C, Wang F. Identification of miR-221 and-222 as important regulators in genotype IV swine hepatitis E virus ORF3-expressingHEK 293 cells[J]. Virus Genes. 2013, 47(1):49-55.
[28] Cheng Y, Du L, Jiao H, Zhu H, Xu K, Guo S, Shi Q, Zhao T, Pang F, Jia X,Wang F. Mmu-miR-27a-5p-Dependent Upregulation of MCPIP1 Inhibits the Inflammatory Response in LPS-Induced RAW264.7 Macrophage Cells[J]. Biomed Res Int. 2015, 2015:607692.
五、成果
1. 2015年泸州市科技进步奖一等奖：代荣阳，冯春红，陈润，付文广，何涛，魏眉等，应激信号调控在肝胆肿瘤中的作用及其临床意义研究。
