万英教授PI团队主要从事肝纤维化、胆汁淤积性肝损伤和酒精性肝病等相关研究。目前，本科研团队有教师4人，其中高级职称2人，初级职称1人，其他人员1人，博士人员占比25%。
团队负责人介绍：
万英：硕士研究生导师，南方医科大学病理学与病理生理学专业博士，美国贝勒斯科怀特研究所和德州农工大学博士后，中国病理生理学会会员、中国病理生理学会第七届消化专业委员会青年工作小组委员，中国医药教育协会智能医学专业委员会委员和四川生理科学会会员，泸州市学术和技术带头人。西南医科大学病理生理学教授，现任西南医科大学病理生理学教研室主任。主持和参与各级科研项目10余项，其中主持国家自然科学基金面上项目1项和四川省科技厅重点研发项目1项。发表SCI论文18篇，主要研究成果发表于Hepatology，American Journal of pathology等专业杂志。万英教授在西南医科大学基础医学院基础医学一级学科硕士学位点招收硕士研究生。招生专业：病理学与病理生理学。
团队成员介绍：
杨朝鲜：教授，人体解剖与组织胚胎学硕士研究生导师，四川大学和加拿大曼尼托巴大学访问学者。参编教材和实习指导10本；先后承担和主研各级科研课题40余项；在国内外杂志发表文章150余篇，其中SCI/EI收录论文30余篇；获四川省科技进步三等奖1项，泸州市科技进步二等奖1项。研究方向：脑损伤与修复。
喻爽：助教，毕业于西南医科大学生物化学与细胞生物学专业，获医学硕士学位，从事肾癌和肝癌相关的研究。目前，已发表SCI论文1篇，获实用新型专利1项。参与厅局级项目1项。
廖婷：毕业于中国医科大学免疫学专业，获医学硕士学位。从事感染免疫相关研究。
团队代表性课题：
1. 国家自然科学基金面上项目，microRNA-34a/SIRT1 信号调控在原发性硬化性胆管炎中的作用及其机制研究。
2. 四川省科学技术厅重点研发项目，非编码RNA在泛血管疾病和缺血性心脏病中的作用与诊疗研究。
3. 泸州市-西南医科大学科技战略合作项目，神经肽P物质和microRNA-21促进胆汁淤积性肝损伤的机制研究。
团队代表性学术成果：
1. Ying Wan#; Fanyin Meng#; Nan Wu; Tianhao Zhou; Julie Venter; Healther Francis; Lindsey Kennedy; Trenton Glaser; Francesca Bernuzzi; Pietro Invernizzi; Shannon Glaser; Qiaobing Huang*; Gianfranco Alpini*; Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells, Hepatology, 2017, 66(2): 528-541
2. Ying Wan; Tianhao Zhou; Elise Slevin; Sachiko Koyama; Xuedong Li; Kelly Harrison; Tian Li; Bingru Zhou; Sugeily Ramos Lorenzo; Yudian Zhang; Wenjuan Xu; James E. Klaunig;Chaodong Wu; Ashok K. Shetty; Chiung‐Kuei Huang; Fanyin Meng; Liver‐specific deletion of microRNA ‐ 34a alleviates ductular reaction and liver fibrosis during experimental cholestasis, The FASEB Journal, 2022, 37(2)：e22731.
3. Ying Wan#; Ludovica Ceci#; Nan Wu; Tianhao Zhou; Lixian Chen; Julie Venter; Heather Francis; Francesca; Bernuzzi; Pietro Invernizzi; Konstantina Kyritsi; Paul Baker; Qiaobing Huang; Chaodong Wu; Amelia Sybenga; Gianfranco Alpini; Fanyin Meng; Shannon Glaser*;Knockout of alpha-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes, Laboratory Investigation, 2019, 99(6)：764-776.
4. Bingru Zhou#; Yudian Zhang#; Xitong Dang; Bowen Li; Wang; Shu Gong; Siwen Li; Fanyin Meng; Juan Xing; Tian Li; Longfei He; Ping Zou*; Ying Wan*; Up-regulation of the human‐specific CHRFAM7A gene protects against renal fibrosis in mice with obstructive nephropathy, Journal of Cellular and Molecular Medicine, 2022, 27(1)：52-65.
5. Siwen Li; Mei Shi; Ying Wan; Yanling Wang; Mei Zhu; Boya Wang; Yangmei Zhan; Bing Ran; Chunlig Wu*; Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity, Ecotoxicology and Environmental Safety, 2020, 201：110801
6. Siwen Li 1, Xiali Wang 1, Yewei Xiao 1, Yanling Wang 1, Ying Wan 1, Xinlian Li 1, Qiuyue Li 1, Xiaoqing Tang 1, Daihong Cai 1, Bing Ran 2, Chunling Wu*; Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway, Ecotoxicol Environ Saf., 2021, 208：111426.
7. Xuelian Zhang; Yaru Qiao; Ronglin Han; Yingjie Gao; Xun Yang; Ying Zhang; Ying Wan; Wei Yu*; Xianchao Pan*; Juan Xing*; A Charcot-Marie-Tooth-Causing Mutation in HSPB1 Decreases Cell Adaptation to Repeated Stress by Disrupting Autophagic Clearance of Hui Misfolded Proteins, Cells, 2022, 11(18)：2886.
8. Ying Wan, Kelly McDaniel, Nan Wu, Sugeily Ramos-Lorenzo, Trenton Glaser, Julie Venter, Heather Francis, Lindsey Kennedy, Keisaku Sato, Tianhao Zhou, Konstantina Kyritsi, Qiaobing Huang , Tami Annable , Chaodong Wu, Shannon Glaser, Gianfranco Alpini, Fanyin Meng. Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury. Am J Pathol. 2017 Dec;187(12):2788-2798.
9. Ying Wan, Elise Slevin, Sachiko Koyama, Chiung-Kuei Huang, Ashok K Shetty, Xuedong Li, Kelly Harrison, Tian Li, Bingru Zhou, Sugeily Ramos Lorenzo, Yudian Zhang, Jennifer Mata Salinas, Wenjuan Xu, James E Klaunig, Chaodong Wu 8, Hidekazu Tsukamoto, Fanyin Meng. miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury. Hepatol Commun. 2023 Apr 4;7(4):e0089.
10. Xuedong Li, Mengrong Wang, Xiang Gao, Chenyu Li, Chunyu Chen, Yun Qi, Ying Wan, Wei Yu. Knockdown of SIRT2 Rescues YARS-induced Charcot-Marie-Tooth Neuropathy in Drosophila. Neurosci Bull. 2024 Apr;40(4):539-543.
