李英，女，博士，副教授。目前主要开展病原菌的致病机制、耐药机制以及耐药菌的综合防控研究。主持或参与国家自然科学基金项目2项，省部级、厅局级等项目十余项，以第一或通讯作者在Commun Biol、Microbiology Spectrum、J Antimicrob Chemoth、Antimicrob Agents Chemother等发表SCI论文30余篇。指导学生获硕士研究生国家奖学金、优秀毕业研究生；指导优秀硕士毕业论文。

研究方向

（1）病原菌致病机制研究；

（2）病原菌耐药机制研究；

（3）病原菌的噬菌体治疗研究。

联系方式（邮件）：

Lying1019@swmu.edu.cn

导师寄语

愿你既有仰望星空的理想，也有扎根实验室的坚守。愿你勇敢、坚定、从容，奔赴属于自己的山海。

承担项目

（1）国家自然科学基金青年基金项目：RhsD蛋白介导blaNDM-1阳性奇异变形杆菌对美罗培南敏感的作用研究(82302576)，2024.01-2026.12，30万元，项目负责人；

（2）西南医科大学-泸州市科技局联合项目：肺炎克雷伯菌RfaH对III型菌毛形成的调控作用研究(2024LZXNYDJ022), 2024.11-2027.10, 20万元，项目负责人。

代表性论文

1) Yin M, Cao L, Fu Y, Lu Y, Yan Y, Qian L, Xiang L, Zhou T, Chen H, Li Y, Zhang L. 2025. A novel tail fiber protein triggers phage DNA ejection by recognizing lipopolysaccharides of K54 hypervirulent Klebsiella pneumoniae. Microbiology Spectrum:e02171-02125.

2) Lu Y, Fang C, Xiang L, Yin M, Qian L, Yan Y, Zhang L, Li Y. 2025. Characterization and Therapeutic Potential of Three Depolymerases Against K54 Capsular-Type Klebsiella pneumoniae. Microorganisms 13:1544.

3) Fu, Y.; Yin, M.; Cao, L.; Lu, Y.; Li, Y.; Zhang, L. Capsule mutations serve as a key strategy of phage resistance evolution of K54 hypervirulent Klebsiella pneumoniae. Communications Biology 2025, 8, 257.

4) Qiu Y, Xiang L, Yin M, Fang C, Dai X, Zhang L, Li Y. 2024. RfaH contributes to maximal colonization and full virulence of hypervirulent Klebsiella pneumoniae. Frontiers in Cellular and Infection Microbiology 14.

5) Li Y, Liu Q, She J, Qiu Y, Dai X, Zhang L. 2023. IS26-mediated in vivo acquisition of bla_KPC-2 in an ST11-K64 Klebsiella pneumoniae isolate from a senile inpatient. Journal of Antimicrobial Chemotherapy 78:550-553.

6) Li Y, Qiu Y, Fang C, Dai X, Zhang L. 2023. Genomic characterisation of a bla_KPC-2- and mcr-10-co-harbouring Enterobacter kobei isolate with high-level resistance to colistin and carbapenems. Journal of Global Antimicrobial Resistance 34:63-66.

7) Li Y, Yin M, Fang C, Fu Y, Dai X, Zeng W, Zhang L. 2023. Genetic analysis of resistance and virulence characteristics of clinical multidrug-resistant Proteus mirabilis isolates. Frontiers in Cellular and Infection Microbiology 13:1229194.

8) Li Y, Liu Q, Qiu Y, Fang C, Zhou Y, She J, Chen H, Dai X, Zhang L. 2022. Genomic characteristics of clinical multidrug-resistant Proteus isolates from a tertiary care hospital in southwest China. Frontiers in Microbiology 13:977356.

9) Li Y, Qiu Y, Fang C, Dai X, Zhang L. 2022. Coexistence of bla_OXA-58 and bla_NDM-1 on a Novel Plasmid of GR59 from an Acinetobacter towneri Isolate. Antimicrobial Agents and Chemotherapy 66:e00206-00222.

10) Li Y, Qiu Y, Fang C, Dai X, Zhang L. 2022. Genomic characterization of a multidrug-resistant Aeromonas caviae isolate carrying a novel bla_KPC-2-harbouring plasmid and an IMP-4-encoding phage-like plasmid. Microbiology Spectrum 10:e00840-00822.