万英，博士，女，1976年9月出生。美国A&M大学博士后，西南医科大学基础医学院病生教研室主任，教授，硕士研究生导师，中国病理生理学会会员和四川生理科学会会员。主要从事肝纤维化、胆汁淤积性肝损伤和酒精性肝病的基础研究，旨在探讨microRNA和细胞衰老在肝脏疾病中的作用，进而为肝纤维化等肝脏疾病的防治提供新的思路和靶点。获得第九批泸州市学术和技术带头人，西南医科大学专业建设先进个人，西南医科大学2020-2023 学年度优秀教师等荣誉。

1. 学习及工作经历

1995.09-2000.06 泸州医学院,临床医学，学士

2003.09-2006.06 泸州医学院，病理学与病理生理学，硕士

2013.09-2017.06 南方医科大学，病理学与病理生理学，博士

2000.07-至今，西南医科大学，基础医学院工作

2. 联系方式

邮箱：yingwan@swmu.edu.cn

3. 研究方向：肝胆疾病的病理生理

4. 承担项目：

（1）国家自然科学基金面上项目：microRNA-34a/SIRT1信号调控在原发性硬化性胆管炎中的作用及其机制研究（81873563），2019.01-2022.12 ，经费57万元；项目负责人。（已结题）

（2）四川省科技厅重点研发项目：非编码RNA在泛血管疾病和缺血性心脏病中的作用与诊疗研究（2022YFS0614），2022.01-2024.12，经费60万元；项目负责人。（在研）

（3）泸州市人民政府-西南医科大学科技战略合作项目：神经肽P 物质和microRNA-21促进胆汁淤积性肝损伤的机制研究（2023LZXNYDJ016），2024.01-2026.12，经费8万元；项目负责人。（在研）

5. 代表性论文：

[1] Ying Wan^# (万英), Fanyin Meng ^#, Nan Wu, Tianhao Zhou, Julie Venter, Heather Francis, Lindsey Kennedy, Trenton Glaser, Francesca Bernuzzi, Pietro Invernizzi, Shannon Glaser, Qiaobing Huang^*, Gianfranco Alpini^*. Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells, Hepatology 2017; 66(2): 528-541.

[2] Ying Wan (万英), Kelly McDaniel, Nan Wu, Sugeily Ramos-Lorenzo, Trenton Glaser, Julie Venter, Heather Francis, Lindsey Kennedy, Keisaku Sato, Tianhao Zhou, Konstantina Kyritsi. Qiaobing Huang, Tami Annable, Chaodong Wu, Shannon Glaser, Gianfranco Alpini^*, Fanyin Meng^*. Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury, Am J Pathol 2017; 187(12): 2788-2798.

[3] Ying Wan^#(万英); Ludovica Ceci^#; Nan Wu; Tianhao Zhou; Lixian Chen; Julie Venter; Heather Francis; Francesca Bernuzzi; Pietro Invernizzi; Konstantina Kyritsi; Paul Baker; Qiaobing Huang; Chaodong Wu; Amelia Sybenga; Gianfranco Alpini^*; Fanyin Meng^*; Shannon Glaser^*. Knockout of α-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes, Lab Invest 2019; 99(6): 764-776.

[4] Bingru Zhou^#; Yudian Zhang^#; Xitong Dang; Bowen Li; Hui Wang; Shu Gong; Siwen Li; Fanyin Meng; Juan Xing; Tian Li; Longfei He; Ping Zou^*; Ying Wan^*(万英); Up-regulation of the human-specific CHRFAM7A gene protects against renal fibrosis in mice with obstructive nephropathy, Journal of Cellular and Molecular Medicine, 2023, 27(1): 52-65.

[5] Ying Wan^#(万英); Tianhao Zhou^#; Elise Slevin; Sachiko Koyama; Xuedong Li; Kelly Harrison; Tian Li; Bingru Zhou; Sugeily Ramos Lorenzo; Yudian Zhang; Wenjuan Xu; James E. Klaunig; Chaodong Wu; Ashok K. Shetty; Chiung-Kuei Huang^*; Fanyin Meng^*; Liver-specific deletion of microRNA-34a alleviates ductular reaction and liver fibrosis during experimental cholestasis, The FASEB Journal, 2023, 37(2): e22731.

[6] Ying Wan(万英); Elise Slevin; Sachiko Koyama; Chiung-Kuei Huang; Ashok K Shetty; Xuedong Li; Kelly Harrison; Tian Li; Bingru Zhou; Sugeily Ramos Lorenzo; Yudian Zhang; Jennifer Mata Salinas; Wenjuan Xu; James E Klaunig; Chaodong Wu; Hidekazu Tsukamoto^*; Fanyin Meng^*; miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury, Hepatol Commun., 2023, 7(4): e0089.

[7] Xuedong Li ^#, Mengrong Wang ^#, Xiang Gao ^#, Chenyu Li, Chunyu Chen, Yun Qi, Ying Wan^*(万英), Wei Yu^*. Knockdown of SIRT2 Rescues YARS-induced Charcot-Marie-Tooth Neuropathy in Drosophila, Neurosci Bull. 2024; 40(4):539-543.